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Title   Hodgkin 씨 병의 방사선 치료 ( Radiotherapy in Hodgkin's Disease )
Publicationinfo   1992 Jan; 024(02): 277-288.
Key_word   Hodgkin's disease, Radiotherapy, Combined modality, Prognostic factors
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Abstract   Results of the treatment of a total of 38 patients with stage I-IIIA Hodgkins disease, who had been treated at Department of Radiation Oncology, Yonsei Cancer Center from July 1980 to June 1988, were analyzed retrospectively. Staging laparotomy was done in 7 patients, and the majority of cases were classified by clini- cal staging(Ann Arbor System: stage IA: 9, IB: 3, IIA: 11, IIB: 7, IIIA: 8). Twenty one patients were treated with radiotherapy alone and l7 with combined modality (chemotherapy+radiotherapy). There were complete responses in 35 of 38 cases(92%). Nine pa- tients developed relapsina Hodgkins disease, and salvage therapy was successful in 64/ of relapsing patients. The overall 5 year actuaria! survival rate and the 5 year reiapse free survival rate were 69% and 47%, respectively. Regardless of treatment modality, 5 year actuarial survival rates of stage I, II and IIIA were 9l%, 63% and 43%, respectively. There was no significant difference of 5 year survival rates between radiotherapy alone and combined modality in patients with stage I and IIA Hodgkins disease(87% vs 85%). The 5 year survival rates in patients with stage IIB and IIIA Hodgkins disease who had been treated radiotherapy alone or combined modality were 53% and 44%, respectively. There was a trend taward increasing survival with combined modality in stage IIB and IIIA Hodgkin's disease while this difference was not statistically significant with the small number of cases involved in this study. We noted that favorable prognostic factors in stage I-IIIA Hodgkin's disease were younger age(less than 30 years old), histology(lymphocyte predominance or nodular selerosis) and earli- er stage. It was difficult to evaluate complications and second malignancies following treatment due to the rather short period of follow-up. Therefore, lona-term follow-up is essential to identify complications of treatment.
저 자   박영환(Kyoung Hwan Koh),서창옥(Chang Ok Suh),김귀언(Gwi Eon Kim),노준규(Jun Kyu Loh)